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1

A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors

James P. Guare, John S. Wai, Robert P. Gomez, Neville J. Anthony, Samson M. Jolly, Amanda R. Cortes, Joseph P. Vacca, Peter J. Felock, Kara A. Stillmock, William A. Schleif, Gregory Moyer, Lori J. Gab

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 159 KB

english, 2006

2

In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

Condra, Jon H., Schleif, William A., Blahy, Olga M., Gabryelski, Lori J., Graham, Donald J., Quintero, Julio, Rhodes, Audrey, Robbins, Helen L., Roth, Elizabeth, Shivaprakash, Malathi

Journal:

Year:

1995

File:

PDF, 318 KB

1995

3

NEW DRUGS IN CHANGE OF

SCHLEIF, WILLIAM

Journal:

AJN American Journal of Nursing

Year:

1901

File:

PDF, 128 KB

1901

4

MATERIA MEDICA, THERAPEUTICS, MEDICAL PHARMACY, PRESCRIPTION-WRITING, AND MEDICAL LATIN

SCHLEIF, WILLIAM

Journal:

The American Journal of the Medical Sciences

Year:

1903

File:

PDF, 121 KB

1903

5

P1′ Oxadiazole Protease Inhibitors with Excellent Activity Against Native and Protease Inhibitor-Resistant HIV-1.

Ronald M. Kim, Elizabeth A. Rouse, Kevin T. Chapman, William A. Schleif, David B. Olsen, Mark Stahlhut, Carrie A. Rutkowski, Emilio A. Emini, James R. Tata

Journal:

Year:

2004

Language:

english

File:

PDF, 34 KB

english, 2004

6

Vero cell-expressed Epstein-Barr virus (EBV) gp350/220 protects marmosets from EBV challenge

Dr. Emilio A. Emini, William A. Schleif, Melvin Silberklang, Dale Lehman, Ronald W. Ellis

Journal:

Journal of Medical Virology

Year:

1989

Language:

english

File:

PDF, 378 KB

english, 1989

7

Synthesis and biological evaluation of 5R- and 5S-methyl substituted d- and l-configuration 1,3-dioxolane nucleoside analogs

Sanjib Bera, Leila Malik, Balkrishen Bhat, Steven S. Carroll, Renee Hrin, Malcolm MacCoss, Daniel R. McMasters, Michael D. Miller, Greg Moyer, David B. Olsen, William A. Schleif, Joanne E. Tomassini,

Journal:

Bioorganic & Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 405 KB

english, 2004

8

A new hydroxyethylamine class of HIV-1 protease inhibitors with high antiviral potency and oral bioavailability

B.Moon Kim, Joseph P. Vacca, James P. Guare, Colleen M. Hanifin, Stuart R. Michelson, PaulL. Darke, Joan A. Zugay, Emilio A. Emini, William Schleif, Jiunn H. Lin, I-Wu Chen, Kari Vastag, Drazen Ostovi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 463 KB

english, 1994

9

Thiophene derivatives as extremely high affinity P3′ ligands for the hydroxyethylpiperazine class of HIV-1 protease inhibitors

B. Moon Kim, James P. Guare, Joseph D. Vacca, Stuart R. Michelson, Paul L. Darke, Joan A. Zugay, Emilio A. Emini, William Schleif, Jiunn H. Lin, I.W. Chen, Kari Vastag, Paul S. Anderson, Joel R. Huff

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 297 KB

english, 1995

10

2-Heterocyclic indole-3-sulfones as inhibitors of HIV-1 reverse transcriptase

Steven D. Young, Muriel C. Amblard, Susan F. Britcher, Vanessa E. Grey, Lee O. Tran, William C. Lumma, Joel R. Huff, William A. Schleif, Emilio E. Emini, Julie A. O'Brien, Douglas J. Pettibone

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 265 KB

english, 1995

11

Substituted alkylpyridines as P3′ ligands for the hydroxyethylpiperazine class of HIV-1 protease inhibitors: Improved pharmacokinetic profiles

B. Moon Kim, Colleen M. Hanifin, C. Blair Zartman, Joseph P. Vacca, Stuart R. Michelson, Jiunn H. Lin, I.-W. Chen, Kari Vastag, Paul L. Darke, Joan A. Zugay, Emilio A. Emini, William Schleif, Paul S.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 277 KB

english, 1995

12

Cycloalkylpiperazines as HIV-1 protease inhibitors: enhanced oral absorption

B. Moon Kim, Ben E. Evans, Kevin F. Gilbert, Colleen M. Hanifin, Joseph P. Vacca, Stuart R. Michelson, Paul L. Darke, Joan A. Zugay, Emilio A. Emini, William Schleif, Jiunn H. Lin, I.-W. Chen, Kari Va

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 287 KB

english, 1995

13

Novel HIV-1 protease inhibitors active against multiple PI-Resistant viral strains: coadministration with indinavir

Nancy J. Kevin, Joseph L. Duffy, Brian A. Kirk, Kevin T. Chapman, William A. Schleif, David B. Olsen, Mark Stahlhut, Carrie A. Rutkowski, Lawrence C. Kuo, Lixia Jin, Jiunn H. Lin, Emilio A. Emini, Jam

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 172 KB

english, 2003

14

P1′ oxadiazole protease inhibitors with excellent activity against native and protease inhibitor-resistant HIV-1

Ronald M. Kim, Elizabeth A. Rouse, Kevin T. Chapman, William A. Schleif, David B. Olsen, Mark Stahlhut, Carrie A. Rutkowski, Emilio A. Emini, James R. Tata

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 272 KB

english, 2004

15

Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors possessing augmented P2′ side chains

Amos B. Smith III, Adam K. Charnley, Hironori Harada, Jason J. Beiger, Louis-David Cantin, Craig S. Kenesky, Ralph Hirschmann, Sanjeev Munshi, David B. Olsen, Mark W. Stahlhut, William A. Schleif, Law

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 217 KB

english, 2006

16

Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus

Subharekha Raghavan, Zhijian Lu, Teresa Beeson, Kevin T. Chapman, William A. Schleif, David B. Olsen, Mark Stahlhut, Carrie A. Rutkowski, Lori Gabryelski, Emilio Emini, James R. Tata

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 156 KB

english, 2007

17

8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors

Thorsten E. Fisher, Boyoung Kim, Donnette D. Staas, Terry A. Lyle, Steven D. Young, Joseph P. Vacca, Matthew M. Zrada, Daria J. Hazuda, Peter J. Felock, William A. Schleif, Lori J. Gabryelski, M. Reza

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 143 KB

english, 2007

18

Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors

H. Marie Langford, Peter D. Williams, Carl F. Homnick, Joseph P. Vacca, Peter J. Felock, Kara A. Stillmock, Marc V. Witmer, Daria J. Hazuda, Lori J. Gabryelski, William A. Schleif

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 140 KB

english, 2008

19

Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase

Jeffrey Y. Melamed, Melissa S. Egbertson, Sandor Varga, Joseph P. Vacca, Greg Moyer, Lori Gabryelski, Peter J. Felock, Kara A. Stillmock, Marc V. Witmer, William Schleif, Daria J. Hazuda, Yvonne Leona

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 202 KB

english, 2008

20

Use of artificial neural networks to determine cognitive impairment and therapeutic effectiveness in Alzheimer's transgenic mice

Ralph E. Leighty, Melissa J. Runfeldt, Donald J. Berndt, William S. Schleif, Jennifer R. Cracchiolo, Huntington Potter, Gary W. Arendash

Journal:

Journal of Neuroscience Methods

Year:

2008

Language:

english

File:

PDF, 473 KB

english, 2008

21

Combinatorial diversification of indinavir: in vivo mixture dosing of an HIV protease inhibitor library

Thomas A Rano, Yuan Cheng, Tracy T Huening, Fengqi Zhang, William A Schleif, Lori Gabryelski, David B Olsen, Lawrence C Kuo, Jiunn H Lin, Xin Xu, Timothy V Olah, Debra A McLoughlin, Richard King, Kevi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 310 KB

english, 2000

22

Combinatorial synthesis of CCR5 antagonists

Christopher A Willoughby, Scott C Berk, Keith G Rosauer, Silvia Degrado, Kevin T Chapman, Sandra L Gould, Martin S Springer, Lorraine Malkowitz, William A Schleif, Daria Hazuda, Michael Miller, Joseph

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 147 KB

english, 2001

23

A Combinatorial Library of Indinavir Analogues and Its In Vitro and In Vivo Studies

Yuan Cheng, Thomas A Rano, Tracy T Huening, Fengqi Zhang, Zhijian Lu, William A Schleif, Lori Gabryelski, David B Olsen, Mark Stahlhut, Lawrence C Kuo, Jiunn H Lin, Xin Xu, Lixia Jin, Timothy V Olah,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 215 KB

english, 2002

24

Synthesis and evaluation of pyridyl analogs of L-735,524: Potent HIV-1 protease inhibitors

Bruce D. Dorsey, Stacey L. McDaniel, Rhonda B. Levin, Joseph P. Vacca, Paul L. Darke, Joan A. Zuga, Emilio A. Emini, William A. Schleif, Jiunn H. Lin, I-W. Chen, M.Katharine Holloway, Paul S. Anderson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 406 KB

english, 1994

25

Indinavir analogues with blocked metabolism sites as HIV protease inhibitors with improved pharmacological profiles and high potency against PI-Resistant viral strains

Yuan Cheng, Fengqi Zhang, Thomas A Rano, Zhijian Lu, William A Schleif, Lori Gabryelski, David B Olsen, Mark Stahlhut, Carrie A Rutkowski, Jiunn H Lin, Lixia Jin, Emilio A Emini, Kevin T Chapman, Jame

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 120 KB

english, 2002

26

1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: polar functionality and its effect on anti-HIV-1 activity

Jeffrey J Hale, Richard J Budhu, Sander G Mills, Malcolm MacCoss, Sandra L Gould, Julie A DeMartino, Martin S Springer, Salvatore J Siciliano, Lorraine Malkowitz, William A Schleif, Daria Hazuda, Mich

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 103 KB

english, 2002

27

Combinatorial library of indinavir analogues: replacement for the aminoindanol at P2′

Subharekha Raghavan, Zheng Yang, Ralph T. Mosley, William A. Schleif, Lori Gabryelski, David B. Olsen, Mark Stahlhut, Lawrence C. Kuo, Emilio A. Emini, Kevin T. Chapman, James R. Tata

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 203 KB

english, 2002

28

The design, synthesis and evaluation of novel HIV-1 protease inhibitors with high potency against PI-resistant viral strains

Fengqi Zhang, Kevin T. Chapman, William A. Schleif, David B. Olsen, Mark Stahlhut, Carrie A. Rutkowski, Lawrence C. Kuo, Lixia Jin, Jiunn H. Lin, Emilio A. Emini, James R. Tata

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 168 KB

english, 2003

29

HIV protease inhibitors with picomolar potency against PI-Resistant HIV-1 by extension of the P3 substituent

Joseph L. Duffy, Thomas A. Rano, Nancy J. Kevin, Kevin T. Chapman, William A. Schleif, David B. Olsen, Mark Stahlhut, Carrie A. Rutkowski, Lawrence C. Kuo, Lixia Jin, Jiunn H. Lin, Emilio A. Emini, Ja

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 184 KB

english, 2003

30

HIV-1 protease inhibitors with picomolar potency against PI-resistant HIV-1 by modification of the P1′ substituent

Joseph L. Duffy, Brian A. Kirk, Nancy J. Kevin, Kevin T. Chapman, William A. Schleif, David B. Olsen, Mark Stahlhut, Carrie A. Rutkowski, Lawrence C. Kuo, Lixia Jin, Jiunn H. Lin, Emilio A. Emini, Jam

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 178 KB

english, 2003

31

Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus

Zhijian Lu, Joann Bohn, Tom Rano, Carrie A. Rutkowski, Amy L. Simcoe, David B. Olsen, William A. Schleif, Anthony Carella, Lori Gabryelski, Lixia Jin, Jiunn H. Lin, Emilio Emini, Kevin Chapman, James

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 136 KB

english, 2005

32

Synthesis and activity of novel HIV protease inhibitors with improved potency against multiple PI-resistant viral strains

Joseph L. Duffy, Nancy J. Kevin, Brian A. Kirk, Kevin T. Chapman, William A. Schleif, David B. Olsen, Mark Stahlhut, Carrie A. Rutkowski, Lawrence C. Kuo, Lixia Jin, Jiunn H. Lin, Emilio A. Emini, Jam

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 122 KB

english, 2002

33

Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus

Zhijian Lu, Subharekha Raghavan, Joann Bohn, Mark Charest, Mark W. Stahlhut, Carrie A. Rutkowski, Amy L. Simcoe, David B. Olsen, William A. Schleif, Anthony Carella, Lori Gabryelski, Lixia Jin, Jiunn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 172 KB

english, 2003

34

Analysis of the HIV-1 gp41 specific immune response using a multiplexed antibody detection assay

David Opalka, Antonello Pessi, Elisabetta Bianchi, Gennaro Ciliberto, William Schleif, Michael McElhaugh, Renee Danzeisen, Romas Geleziunas, Michael Miller, Debra M. Eckert, David Bramhill, Joseph Joy

Journal:

Journal of Immunological Methods

Year:

2004

Language:

english

File:

PDF, 1.19 MB

english, 2004

35

The impact of early immune destruction on the kinetics of postacute viral replication in rhesus monkey infected with the simian-human immunodeficiency virus 89.6P

Zhi-Qiang Zhang, William A Schleif, Danilo R Casimiro, Larry Handt, Minchun Chen, Mary-Ellen Davies, Xiaoping Liang, Tong-Ming Fu, Aimin Tang, Keith A Wilson, Michael McElhaugh, Anthony Carella, Charl

Journal:

Year:

2004

Language:

english

File:

PDF, 804 KB

english, 2004

36

The effect of early versus delayed challenge after vaccination in controlling SHIV 89.6P infection

Leslie L. Chavez, Miles P. Davenport, John W. Shiver, Lynda G. Tussey, Kara S. Cox, Margaret Bachinsky, Fubao Wang, Lingyi Huang, William A. Schleif, Mary-Ellen Davies, Aimin Tang, Danilo R. Casimiro,

Journal:

Year:

2008

Language:

english

File:

PDF, 727 KB

english, 2008

37

Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl design

Thompson, Wayne J., Fitzgerald, Paula M. D., Holloway, M. Katharine, Emini, Emilio A., Darke, Paul L., McKeever, Brian M., Schleif, William A., Quintero, Julio C., Zugay, Joan A.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 6.11 MB

english, 1992

38

Antigenic conservation and divergence between the viral-specific proteins of poliovirus type 1 and various picornaviruses

Emilio A. Emini, William A. Schleif, Richard J. Colonno, Eckard Wimmer

Journal:

Year:

1985

Language:

english

File:

PDF, 1.97 MB

english, 1985

39

O1-01-01: Caffeine: Evidence for protection against, and treatment for, Alzheimer’s disease by direct suppression of disease pathogenesis

Gary W. Arendash, Kavon Rezai-Zadeh, Chuanhai Cao, Malgorzata Mamcarz, Alexander Dickson, William Schleif, Melissa Runfeldt, Xiaoyang Lin, Jennifer Cracchiolo, Daniel Shippy, Ashok Raj, Jun Tan, Hunti

Journal:

Alzheimer's & Dementia

Year:

2007

Language:

english

File:

PDF, 145 KB

english, 2007

40

Early depletion of proliferating B cells of germinal center in rapidly progressive simian immunodeficiency virus infection

Zhi-Qiang Zhang, Danilo R. Casimiro, William A. Schleif, Minchun Chen, Michael Citron, Mary-Ellen Davies, Janine Burns, Xiaoping Liang, Tong-Ming Fu, Larry Handt, Emilio A. Emini, John W. Shiver

Journal:

Year:

2007

Language:

english

File:

PDF, 556 KB

english, 2007

41

Regulation of the Escherichia coli l-arabinose operon studied by gel electrophoresis DNA binding assay

William Hendrickson, Robert F. Schleif

Journal:

Journal of Molecular Biology

Year:

1984

Language:

english

File:

PDF, 2.74 MB

english, 1984

42

Transcription of Escherichia coli ara in vitro: The cyclic AMP receptor protein requirement for PBAD induction that depends on the presence and orientation of the araO2 site

Steven Hahn, William Hendrickson, Robert Schleif

Journal:

Journal of Molecular Biology

Year:

1986

Language:

english

File:

PDF, 4.32 MB

english, 1986

43

The immune response to poliovirus-specific synthetic peptides: Effects of adjuvants and test animal species

Emilio A. Emini, William A. Schleif, Bradford A. Jameson, Eckard Wimmer

Journal:

Journal of Virological Methods

Year:

1985

Language:

english

File:

PDF, 440 KB

english, 1985

44

A microtiter cell-culture assay for the determination of anti-human immunodeficiency virus neutralizing antibody activity

George A. Robertson, Beverly M. Kostek, William A. Schleif, John A. Lewis, Emilio A. Emini

Journal:

Journal of Virological Methods

Year:

1988

Language:

english

File:

PDF, 482 KB

english, 1988

45

Characterization of the Escherichia coli araFGH and araJ promoters

William Hendrickson, Carol Stoner, Robert Schleif

Journal:

Journal of Molecular Biology

Year:

1990

Language:

english

File:

PDF, 5.21 MB

english, 1990

46

Pyrrolinone-Based HIV Protease Inhibitors. Design, Synthesis, and Antiviral Activity: Evidence for Improved Transport

Smith, Amos B, Hirschmann, Ralph, Pasternak, Alexander, Guzman, Mark C., Yokoyama, Akihisa, Sprengeler, Paul A., Darke, Paul L., Emini, Emilio A., Schleif, William A.

Journal:

Journal of the American Chemical Society

Year:

1995

Language:

english

File:

PDF, 2.40 MB

english, 1995

47

L-735,524: The Design of a Potent and Orally Bioavailable HIV Protease Inhibitor

Dorsey, Bruce D., Levin, Rhonda B., McDaniel, Stacy L., Vacca, Joseph P., Guare, James P., Darke, Paul L., Zugay, Joan A., Emini, Emilio A., Schleif, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 2.17 MB

english, 1994

48

Benzocycloalkyl amines as novel C-termini for HIV protease inhibitors

Lyle, Terry A., Wiscount, Catherine M., Guare, James P., Thompson, Wayne J., Anderson, Paul S., Darke, Paul L., Zugay, Joan A., Emini, Emilio A., Schleif, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 339 KB

english, 1991

49

Identification of MK-944a: A Second Clinical Candidate from the Hydroxylaminepentanamide Isostere Series of HIV Protease Inhibitors

Dorsey, Bruce D., McDonough, Colleen, McDaniel, Stacey L., Levin, Rhonda B., Newton, Christina L., Hoffman, Jacob M., Darke, Paul L., Zugay-Murphy, Joan A., Emini, Emilio A., Schleif, William A., Olse

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 228 KB

english, 2000

50

A Dimer of AraC Protein Contacts Three Adjacent Major Groove Regions of the araI DNA Site

William Hendrickson and Robert Schleif

Journal:

Proceedings of the National Academy of Sciences

Year:

1985

Language:

english

File:

PDF, 1.56 MB

english, 1985

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